Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
Identifieur interne : 000438 ( new/Analysis ); précédent : 000437; suivant : 000439Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity.
Auteurs : Weilie Chen [République populaire de Chine] ; Yun Lan [République populaire de Chine] ; Xiaozhen Yuan [République populaire de Chine] ; Xilong Deng [République populaire de Chine] ; Yueping Li [République populaire de Chine] ; Xiaoli Cai [République populaire de Chine] ; Liya Li [République populaire de Chine] ; Ruiying He [République populaire de Chine] ; Yizhou Tan [République populaire de Chine] ; Xizi Deng [République populaire de Chine] ; Ming Gao [République populaire de Chine] ; Guofang Tang [République populaire de Chine] ; Lingzhai Zhao [République populaire de Chine] ; Jinlin Wang [République populaire de Chine] ; Qinghong Fan [République populaire de Chine] ; Chunyan Wen [République populaire de Chine] ; Yuwei Tong [République populaire de Chine] ; Yangbo Tang [République populaire de Chine] ; Fengyu Hu [République populaire de Chine] ; Feng Li [République populaire de Chine] ; Xiaoping Tang [République populaire de Chine]Source :
- Emerging microbes & infections [ 2222-1751 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- génétique : ARN viral.
- sang : ARN viral.
- virologie : Infections à coronavirus, Pneumopathie virale.
- Humains, Indice de gravité médicale, Réaction de polymérisation en chaine en temps réel, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : RNA, Viral.
- genetics : Betacoronavirus, RNA, Viral.
- isolation & purification : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Humans, Real-Time Polymerase Chain Reaction, Retrospective Studies, Severity of Illness Index.
Abstract
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.
DOI: 10.1080/22221751.2020.1732837
PubMed: 32102625
Affiliations:
Links toward previous steps (curation, corpus...)
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- to stream new, to step Extraction: 000438
Links to Exploration step
pubmed:32102625Le document en format XML
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Chen</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Lan, Yun" sort="Lan, Yun" uniqKey="Lan Y" first="Yun" last="Lan">Yun Lan</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Yuan, Xiaozhen" sort="Yuan, Xiaozhen" uniqKey="Yuan X" first="Xiaozhen" last="Yuan">Xiaozhen Yuan</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Deng, Xilong" sort="Deng, Xilong" uniqKey="Deng X" first="Xilong" last="Deng">Xilong Deng</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Li, Yueping" sort="Li, Yueping" uniqKey="Li Y" first="Yueping" last="Li">Yueping Li</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Cai, Xiaoli" sort="Cai, Xiaoli" uniqKey="Cai X" first="Xiaoli" last="Cai">Xiaoli Cai</name><affiliation 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type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="He, Ruiying" sort="He, Ruiying" uniqKey="He R" first="Ruiying" last="He">Ruiying He</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Tan, Yizhou" sort="Tan, Yizhou" uniqKey="Tan Y" first="Yizhou" last="Tan">Yizhou Tan</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Deng, Xizi" sort="Deng, Xizi" uniqKey="Deng X" first="Xizi" last="Deng">Xizi Deng</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Tang, Guofang" sort="Tang, Guofang" uniqKey="Tang G" first="Guofang" last="Tang">Guofang Tang</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhao, Lingzhai" sort="Zhao, Lingzhai" uniqKey="Zhao L" first="Lingzhai" last="Zhao">Lingzhai Zhao</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Jinlin" sort="Wang, Jinlin" uniqKey="Wang J" first="Jinlin" last="Wang">Jinlin Wang</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Fan, Qinghong" sort="Fan, Qinghong" uniqKey="Fan Q" first="Qinghong" last="Fan">Qinghong Fan</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wen, Chunyan" sort="Wen, Chunyan" uniqKey="Wen C" first="Chunyan" last="Wen">Chunyan Wen</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Tong, Yuwei" sort="Tong, Yuwei" uniqKey="Tong Y" first="Yuwei" last="Tong">Yuwei Tong</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Tang, Yangbo" sort="Tang, Yangbo" uniqKey="Tang Y" first="Yangbo" last="Tang">Yangbo Tang</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Hu, Fengyu" sort="Hu, Fengyu" uniqKey="Hu F" first="Fengyu" last="Hu">Fengyu Hu</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name><affiliation wicri:level="3"><nlm:affiliation>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">Emerging microbes & infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Betacoronavirus (genetics)</term><term>Betacoronavirus (isolation & purification)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Pneumonia, Viral (virology)</term><term>RNA, Viral (blood)</term><term>RNA, Viral (genetics)</term><term>Real-Time Polymerase Chain Reaction</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>ARN viral (sang)</term><term>Humains</term><term>Indice de gravité médicale</term><term>Infections à coronavirus (virologie)</term><term>Pneumopathie virale (virologie)</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Real-Time Polymerase Chain Reaction</term><term>Retrospective Studies</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Indice de gravité médicale</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (<i>p</i>-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Chen, Weilie" sort="Chen, Weilie" uniqKey="Chen W" first="Weilie" last="Chen">Weilie Chen</name></region><name sortKey="Cai, Xiaoli" sort="Cai, Xiaoli" uniqKey="Cai X" first="Xiaoli" last="Cai">Xiaoli Cai</name><name sortKey="Deng, Xilong" sort="Deng, Xilong" uniqKey="Deng X" first="Xilong" last="Deng">Xilong Deng</name><name sortKey="Deng, Xizi" sort="Deng, Xizi" uniqKey="Deng X" first="Xizi" last="Deng">Xizi Deng</name><name sortKey="Fan, Qinghong" sort="Fan, Qinghong" uniqKey="Fan Q" first="Qinghong" last="Fan">Qinghong Fan</name><name sortKey="Gao, Ming" sort="Gao, Ming" uniqKey="Gao M" first="Ming" last="Gao">Ming Gao</name><name sortKey="He, Ruiying" sort="He, Ruiying" uniqKey="He R" first="Ruiying" last="He">Ruiying He</name><name sortKey="Hu, Fengyu" sort="Hu, Fengyu" uniqKey="Hu F" first="Fengyu" last="Hu">Fengyu Hu</name><name sortKey="Lan, Yun" sort="Lan, Yun" uniqKey="Lan Y" first="Yun" last="Lan">Yun Lan</name><name sortKey="Li, Feng" sort="Li, Feng" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><name sortKey="Li, Liya" sort="Li, Liya" uniqKey="Li L" first="Liya" last="Li">Liya Li</name><name sortKey="Li, Yueping" sort="Li, Yueping" uniqKey="Li Y" first="Yueping" last="Li">Yueping Li</name><name sortKey="Tan, Yizhou" sort="Tan, Yizhou" uniqKey="Tan Y" first="Yizhou" last="Tan">Yizhou Tan</name><name sortKey="Tang, Guofang" sort="Tang, Guofang" uniqKey="Tang G" first="Guofang" last="Tang">Guofang Tang</name><name sortKey="Tang, Xiaoping" sort="Tang, Xiaoping" uniqKey="Tang X" first="Xiaoping" last="Tang">Xiaoping Tang</name><name sortKey="Tang, Yangbo" sort="Tang, Yangbo" uniqKey="Tang Y" first="Yangbo" last="Tang">Yangbo Tang</name><name sortKey="Tong, Yuwei" sort="Tong, Yuwei" uniqKey="Tong Y" first="Yuwei" last="Tong">Yuwei Tong</name><name sortKey="Wang, Jinlin" sort="Wang, Jinlin" uniqKey="Wang J" first="Jinlin" last="Wang">Jinlin Wang</name><name sortKey="Wen, Chunyan" sort="Wen, Chunyan" uniqKey="Wen C" first="Chunyan" last="Wen">Chunyan Wen</name><name sortKey="Yuan, Xiaozhen" sort="Yuan, Xiaozhen" uniqKey="Yuan X" first="Xiaozhen" last="Yuan">Xiaozhen Yuan</name><name sortKey="Zhao, Lingzhai" sort="Zhao, Lingzhai" uniqKey="Zhao L" first="Lingzhai" last="Zhao">Lingzhai Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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